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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL3
All Species:
24.55
Human Site:
Y154
Identified Species:
36
UniProt:
Q13618
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13618
NP_003581.1
768
88930
Y154
F
R
D
Q
V
V
R
Y
G
C
I
R
D
H
L
Chimpanzee
Pan troglodytes
XP_001167451
757
87889
L155
D
H
L
R
Q
T
L
L
D
M
I
A
R
E
R
Rhesus Macaque
Macaca mulatta
XP_001109600
746
86448
K152
D
M
I
A
R
E
R
K
G
E
V
V
D
R
G
Dog
Lupus familis
XP_534586
746
86477
K152
D
M
I
A
R
E
R
K
G
E
V
V
D
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLV5
768
88930
Y154
F
R
D
Q
V
V
R
Y
G
C
I
R
D
H
L
Rat
Rattus norvegicus
Q9JJ31
780
90872
L162
L
Q
D
S
A
M
K
L
V
H
A
E
R
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512511
642
74121
Y75
G
L
E
G
R
S
V
Y
E
E
D
F
E
A
P
Chicken
Gallus gallus
XP_422620
768
88957
Y154
F
R
D
Q
V
V
R
Y
G
C
I
R
D
H
L
Frog
Xenopus laevis
Q6DE95
768
88933
Y154
F
R
D
Q
V
V
R
Y
G
C
I
R
D
H
L
Zebra Danio
Brachydanio rerio
NP_955985
766
89011
Y152
F
R
D
Q
V
V
R
Y
G
C
I
R
D
H
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
K159
R
L
A
L
V
A
W
K
G
H
L
F
Q
V
L
Honey Bee
Apis mellifera
XP_625079
767
89385
Y151
F
R
D
Q
V
V
R
Y
G
C
V
R
D
H
L
Nematode Worm
Caenorhab. elegans
Q17391
777
90217
R151
A
Y
R
T
E
I
L
R
Q
N
G
I
G
D
R
Sea Urchin
Strong. purpuratus
XP_001178314
675
78472
D108
M
L
M
V
L
G
I
D
S
R
S
V
Y
M
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
E159
V
I
A
L
V
D
K
E
R
E
G
E
Q
I
D
Baker's Yeast
Sacchar. cerevisiae
P53202
744
86097
S154
K
C
S
S
S
L
I
S
A
L
I
S
D
I
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
97.1
96.8
N.A.
99.4
26.4
N.A.
83.1
99.6
98.5
95.9
N.A.
28.4
77.2
49.6
67
Protein Similarity:
100
98
97.1
96.8
N.A.
99.6
49.4
N.A.
83.3
99.7
99.2
98.3
N.A.
52.4
87.5
69.1
76.9
P-Site Identity:
100
6.6
20
20
N.A.
100
6.6
N.A.
6.6
100
100
100
N.A.
20
93.3
0
0
P-Site Similarity:
100
13.3
26.6
26.6
N.A.
100
26.6
N.A.
20
100
100
100
N.A.
26.6
100
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.3
26.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.5
46.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
13
13
7
7
0
0
7
0
7
7
0
7
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
38
0
0
0
0
0
% C
% Asp:
19
0
44
0
0
7
0
7
7
0
7
0
57
7
7
% D
% Glu:
0
0
7
0
7
13
0
7
7
25
0
13
7
7
13
% E
% Phe:
38
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% F
% Gly:
7
0
0
7
0
7
0
0
57
0
13
0
7
0
19
% G
% His:
0
7
0
0
0
0
0
0
0
13
0
0
0
38
0
% H
% Ile:
0
7
13
0
0
7
13
0
0
0
44
7
0
13
0
% I
% Lys:
7
0
0
0
0
0
13
19
0
0
0
0
0
0
0
% K
% Leu:
7
19
7
13
7
7
13
13
0
7
7
0
0
7
44
% L
% Met:
7
13
7
0
0
7
0
0
0
7
0
0
0
7
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
7
0
38
7
0
0
0
7
0
0
0
13
0
0
% Q
% Arg:
7
38
7
7
19
0
50
7
7
7
0
38
13
13
13
% R
% Ser:
0
0
7
13
7
7
0
7
7
0
7
7
0
0
0
% S
% Thr:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
7
0
0
7
50
38
7
0
7
0
19
19
0
7
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
44
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _